The diagnostic role of AIM2 in Kawasaki disease
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ORIGINAL ARTICLE
The diagnostic role of AIM2 in Kawasaki disease Zhenquan Wang1 · Qiaoyu Wang1 · Jiahui Jin1 · Xing Rong1 · Tingting Wu1 · Huixian Qiu1 · Rongzhou Wu1 Received: 18 May 2020 / Accepted: 3 October 2020 © Springer Nature Switzerland AG 2020
Abstract Kawasaki disease (KD), a systemic vasculitis in children, may bring serious complications. However, the etiology of KD remains unclear. AIM2, an intracellular receptor, plays a vital role during the infection caused by a variety of pathogens. However, its role in KD remains unclear. The principal aim of the present research is to concentrate on the relation between AIM2 and KD. We detected the levels of AIM2, IL-18 and IL-1β in all subjects by ELISA. The conventional inflammatory indices were detected in all subjects, such as WBC, HB, CRP and so on. The serum concentrations of AIM2, IL-18 and IL-1β were notably upregulated in the KD group compared to the febrile group and healthy group, respectively. And the three indicators in the KD patients were greatly reduced after interpreted with IVIG. Furthermore, the expressions of IL-18 and IL-1β were positively correlated with AIM2. Meanwhile, the cutoff value of serum AIM2 level for the diagnosis of KD was 541.90 ng/L with the specificity of 60% and sensitivity of 92.5%, compared to the febrile controls. And the area under curve (AUC) of AIM2 was 0.771. And no difference was observed in patients with CALs when compared with patients without CALs. The serum AIM2, IL-18 and IL-1β might play a critical role during the progress of KD. AIM2 can be considered as a candidate indicator for Kawasaki disease diagnosis. Keywords AIM2 · IL-18 · IL-1β · Kawasaki disease · Intravenous immunoglobulin · Coronary artery lesions
Introduction Kawasaki disease (KD), a systemic vasculitis syndrome, occurs preferentially in coronary arteries of infants and children [1]. The etiology of KD has not been clearly clarified, and clinical diagnosis is mainly based on manifestation. At the acute stage of KD, nearly 25% of patients will develop coronary artery dilatation without timely treatment [2]. So how to early pick out KD from febrile disease is very important. Inflammatory signaling has a critical function in occurrences of cardiovascular diseases such as KD, coronary ischemia and cardiomyopathy [3].Up to now, there is no exact laboratory diagnostic indicator for KD except for the inflammatory indices including platelet (PLT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Zhenquan Wang and Qiaoyu Wang contributed equally to this work. * Rongzhou Wu [email protected] 1
Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
In the study of Song et al., the specificity of CRP for the prediction of KD was 72.7% and sensitivity was 69.0%, and the specificity and sensitivity of PLT were 75 and 70.6% [4]. Many proinflammatory cytokines are significantly upregulated at the early phases of KD. Su et al. identified increased leve
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