The DNA, RNA, and Histone Methylomes
This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in ce
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Stefan Jurga Jan Barciszewski Editors
The DNA, RNA, and Histone Methylomes
RNA Technologies
Series Editors Jan Barciszewski, Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland Institute of Bioorganic Chemistry of the Polish, Academy of Sciences, Poznań, Poland Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Berlin, Germany Founding Editor Volker A. Erdmann, Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany
More information about this series at http://www.springer.com/series/8619
Stefan Jurga • Jan Barciszewski Editors
The DNA, RNA, and Histone Methylomes
Editors Stefan Jurga Nanobiomedical Center Adam Mickiewicz University Poznań, Poland
Jan Barciszewski Nanobiomedical Center Adam Mickiewicz University Poznań, Poland Institute of Bioorganic Chemistry of the Polish Academy of Sciences Poznań, Poland
ISSN 2197-9731 ISSN 2197-9758 (electronic) RNA Technologies ISBN 978-3-030-14791-4 ISBN 978-3-030-14792-1 (eBook) https://doi.org/10.1007/978-3-030-14792-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Chromatin Methylome In eukaryotes, the genome size is highly variable between organisms. It is organized into chromatin, a nuclear complex encompassing DNA, RNA, and associated proteins. Furthermore, chromatin is organized into two distinct domains, namely, euchromatin and heterochromatin, depending on the compaction state. Euchromatin exhibits relatively loose compaction and is typically transcriptionally permissive, whereas heterochromatin is more condensed, rich in repetitive sequences, and typically transcriptionally
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