DNA and Histone Methylation as Cancer Targets
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histo
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Atsushi Kaneda Yu-ichi Tsukada Editors
DNA and Histone Methylation as Cancer Targets
Cancer Drug Discovery and Development
Series editor: Beverly A. Teicher Bethesda, MD, USA The Cancer Drug Discovery and Development series (Beverly A Teicher, series editor) is the definitive book series in cancer research and oncology, providing comprehensive coverage of specific topics and the field. Volumes cover the process of drug discovery, preclinical models in cancer research, specific drug target groups and experimental and approved therapeutic agents. The volumes are current and timely, anticipating areas where experimental agents are reaching FDA approval. Each volume is edited by an expert in the field covered and chapters are authored by renowned scientists and physicians in their fields of interest. More information about this series at http://www.springer.com/series/7625
Atsushi Kaneda • Yu-ichi Tsukada Editors
DNA and Histone Methylation as Cancer Targets
Editors Atsushi Kaneda Graduate School of Medicine Chiba University Chiba, Chiba, Japan
Yu-ichi Tsukada Advanced Biological Information Research Division, INAMORI Frontier Research Center Kyushu University Fukuoka, Fukuoka, Japan
ISSN 2196-9906 ISSN 2196-9914 (electronic) Cancer Drug Discovery and Development ISBN 978-3-319-59784-3 ISBN 978-3-319-59786-7 (eBook) DOI 10.1007/978-3-319-59786-7 Library of Congress Control Number: 2017943960 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
Epigenetics is a novel dogma that regulates gene expression profiles in the cells and is known to be involved in cancer. Among nume
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