The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases
- PDF / 8,354,079 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 89 Downloads / 155 Views
Journal of Nanobiotechnology Open Access
RESEARCH
The double‑edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases Yuchuan Yuan1†, Ling Long4†, Jiaxing Liu1†, Yongyao Lin1, Cuiping Peng1, Yue Tang2, Xuemei Zhou2, Shuhui Li3, Chengyuan Zhang2*, Xiaohui Li1* and Xing Zhou2*
Abstract Background: Monocyte/macrophage-targeting delivery systems (MTDSs) have been focused upon as an emerging routine for delivering drugs to treat various macrophage-related diseases. However, the ability of MTDSs to distinguish different macrophage-related diseases and their impact on macrophage function and disease progression have not been systematically revealed, which is important for actively targeted therapeutic or diagnostic strategies. Results: Herein, we used dextran-modified polystyrene nanoparticles (DEX-PS) to demonstrate that modification of nanoparticles by dextran can specifically enhance their recognition by M2 macrophages in vitro, but it is obstructed by monocytes in peripheral blood according to in vivo assays. DEX-PS not only targeted and became distributed in tumors, an M2 macrophage-related disease, but was also highly distributed in an M1 macrophage-related disease, namely acute peritonitis. Thus, DEX-PS acts as a double-edged sword in these two different diseases by reeducating macrophages to a pro-inflammatory phenotype. Conclusions: Our results suggest that MTDSs, even those designed based on differential expression of receptors on specific macrophage subtypes, lack the ability to distinguish different macrophage subtype-related diseases in vivo. In addition to the potential impact of these carrier materials on macrophage function, studies of MTDSs should pay greater attention to the distribution of nanoparticles in non-target macrophage-infiltrated disease sites and their impact on disease processes. Keywords: Macrophage, Targeting mechanism, Dextran modification, Macrophage related disease, Targeted delivery system
*Correspondence: [email protected]; [email protected]; [email protected]; [email protected] † Yuchuan Yuan, Ling Long and Jiaxing Liu contributed equally to this work 1 Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing 400038, China 2 School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China Full list of author information is available at the end of the article © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and yo
Data Loading...
