The Effectiveness of Potential Probiotics Lactobacillus rhamnosus Vahe and Lactobacillus delbrueckii IAHAHI in Irradiate
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The Effectiveness of Potential Probiotics Lactobacillus rhamnosus Vahe and Lactobacillus delbrueckii IAHAHI in Irradiated Rats Depends on the Nutritional Stage of the Host Astghik Z. Pepoyan 1,2 & Anahit M. Manvelyan 1 & Marine H. Balayan 1 & Gavin McCabe 3 & Vardan V. Tsaturyan 2,4 & Vyacheslav G. Melnikov 5 & Michael L. Chikindas 6,7 & Richard Weeks 6 & Andrey V. Karlyshev 3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Several species of eukaryotic organisms living in the high mountain areas of Armenia with naturally occurring levels of radiation have high adaptive responses to radiation. We speculate on the role of the gastrointestinal microbiota in this protection against radiation. Therefore, seventeen microorganisms with high antagonistic activities against several multi-drug-resistant pathogens were isolated from the human and animal gut microbiota, as well as from traditional Armenian fermented products. These strains were tested in vivo on Wistar rats to determine their ability to protect the eukaryotic host against radiation damages. The efficiency of the probiotics’ application and the dependence on pre- and post-radiation nutrition of rats were described. The effects of Lactobacillus rhamnosus Vahe, isolated from a healthy breastfed infant, and Lactobacillus delbrueckii IAHAHI, isolated from the fermented dairy product matsuni, on the survival of irradiated rats, and their blood leucocyte and glucose levels, were considered to be the most promising, based on this study’s results. Keywords X-ray irradiation . Probiotic . Blood glucose level . Radiation damages . Vitamins . Pre- and post-radiation effects
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12602-020-09662-7) contains supplementary material, which is available to authorized users. * Astghik Z. Pepoyan [email protected] 1
Department of Food Safety and Biotechnology, Armenian National Agrarian University, Teryan 74, 0009 Yerevan, Armenia
2
International Association for Human and Animals Health Improvement, Azatutyan 11, 0037 Yerevan, Armenia
3
Department of Biomolecular Sciences, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames KT1 2EE, UK
4
Yerevan State Medical University, 0009 Yerevan, Armenia
5
Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, Moscow, Russia 125212
6
Health Promoting Naturals Laboratory, Rutgers State University, New Brunswick, NJ, USA
7
Don State Technical University, Rostov-on-Don, Russia
There is an emerging interest in the effects of natural radiation (NR) (radioactivity in the rocks and soil of the earth’s crust, cosmic radiation, etc.) on the health of humans and other animals [1–4]. The potential risk of radiation accidents is also increasing, especially in developing or politically unstable countries or those with aging nuclear infrastructure. At the same time, exposures to doses of radiation of 1–10 Gy, defined as mod
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