The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis
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(2020) 18:235
RESEARCH
Open Access
The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis Zhongjie Huang1†, Jianming Zheng2†, Wencheng Huang1, Meihao Yan1, Liyue Hong1, Yuancheng Hong1*, Runnv Jin1, Xincheng Huang1, Hongtao Fan1, Huiling Chen1, Heping Yang1, Weiping Su1 and Xiaoping Huang1
Abstract Background: Several randomized controlled trials (RCTs) have compared the treatment of acute lung injury (ALI) with omega-3 fatty, yet the results remained inconsistent. Therefore, we attempted this meta-analysis to analyze the role of omega-3 fatty in the treatment of ALI patients. Methods: We searched PubMed databases from inception date to October 31, 2019, for RCTs that compared the treatment of ALI with or without omega-3 fatty. Two authors independently screened the studies and extracted data from the published articles. Summary mean differences (MD) with 95% confidence intervals (CI) were calculated for each outcome by fixed- or random-effects model. Results: Six RCTs with a total of 277 patients were identified, of whom 142 patients with omega-3 fatty acid treatment and 135 patients without omega-3 fatty treatment. Omega-3 fatty treatments significantly improve the PaO2 (MD = 13.82, 95% CI 8.55–19.09), PaO2/FiO2 (MD = 33.47, 95% CI 24.22–42.72), total protein (MD = 2.02, 95% CI 0.43–3.62) in ALI patients, and omega-3 fatty acid treatments reduced the duration of mechanical ventilation (MD = − 1.72, 95% CI − 2.84 to − 0.60) and intensive care unit stay (MD = − 1.29, 95% CI − 2.14 to − 0.43) in ALI patients. Conclusions: Omega-3 fatty can effectively improve the respiratory function and promote the recovery of ALI patients. Future studies focused on the long-term efficacy and safety of omega-3 fatty use for ALI are needed. Keywords: Omega-3 fatty, Acute lung injury, Treatment, Meta-analysis, Review
Background Acute lung injury (ALI) is a very common kind of critically ill disease in the clinic, which is caused by various intrapulmonary and external factors such as severe trauma, shock, acidosis, or serious infection [1, 2]. If left untreated, it may progress into acute respiratory distress syndrome (ARDS) with high mortality [3]. In the past decade, great progress has been made in the management of * Correspondence: [email protected] † Zhongjie Huang and Jianming Zheng contributed equally to this work. 1 Department of Respiratory Medicine, Quanzhou Strait Hospital, No.180 Huayuan Road, Fengze District, Quanzhou 362000, Fujian Province, China Full list of author information is available at the end of the article
patients with ALI and ARDS. However, the mortality of ALI/ARDS is still high with a range of 40 to 31% [4, 5]. In addition to infection control, low tidal volume protective lung mechanical ventilation and nutritional treatment of ARDS/ALI play an important role in the treatment strategies [6–8], especially the provision of calories by fat nutrition is a key part [9]. At present, the fat emulsions used in clinical practice are mostly based on soybean oil
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