The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review a
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The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials Javad Heshmati 1 & Farnaz Farsi 2,3 & Somaye Yosaee 4,5 & Maryam Razavi 6 & Mahroo Rezaeinejad 7 & Elham Karimie 7 & Mahdi Sepidarkish 8 Published online: 13 December 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018
Abstract We searched bibliographic databases from inception through May 2018 to evaluate the effect of probiotics (or synbiotics) supplementation in women suffering from polycystic ovary syndrome (PCOS). Seven trials involving 236 women with PCOS and 235 controls were included in the meta-analysis. Comparing with the control group, probiotics (or synbiotics) may improve Quantitative insulin sensitivity check index (QUICKI) (standardized mean difference (SMD) 0.41, 95% confidence intervals (CI) 0.01 to 0.82, P = 0.04), decrease triglyceride (TG) level (mean difference (MD) − 17.51 mg/dL, 95% CI − 29.65 to − 5.36); fasting insulin: (MD − 2.14 μIU/mL, 95% CI − 4.24 to − 0.04), and increase high-density lipoprotein (HDL) (SMD 1.55 mg/dL, 95% CI 0.28 to 2.81). No significant effect of probiotics (or synbiotics) on homeostatic model assessment-insulin resistance (HOMA-IR), fasting plasma glucose (FPG), low-density lipoprotein (LDL), total cholesterol (TC), and anthropometric indices was found in women with PCOS. Although probiotic (or synbiotics) supplementation was effective on some metabolic indices, the effect was negligible and not clinically significant. Keywords Probiotics . Synbiotics . Insulin resistance . Polycystic ovary syndrome
Introduction PCOS, an endocrine disorder, is one of the most prominent causes of infertility in reproductive-aged women [1, 2]. According to available evidence, PCOS accounts for 70% of anovulatory infertility [3]. Ovarian enlargement, hyperandrogenism, acne, and hirsutism are main clinical
features of women affected by PCOS [4]. Furthermore PCOS women are also at higher risk of developing metabolic disorder such as glucose intolerance [5], β-cell dysfunction [6], inflammation [7], obesity, and dyslipidemia [8]. Several treatment methods are used in management of PCOS patients, like insulin sensitizers, lifestyle changes, and dietary interventions. Insulin sensitizer medication is currently
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12602-018-9493-9) contains supplementary material, which is available to authorized users. * Mahdi Sepidarkish [email protected]
5
Department of Nutrition, Emam Reza teaching hospital, Larestan University of Medical Sciences, Larestan, Iran
1
Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
6
Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2
Colorectal research center, Iran University of Medi
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