The mental health of women with polycystic ovary syndrome: a systematic review and meta-analysis
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REVIEW ARTICLE
The mental health of women with polycystic ovary syndrome: a systematic review and meta-analysis Xican Yin 1 & Yinan Ji 1 & Cecilia Lai Wan Chan 1 & Celia Hoi Yan Chan 1,2 Received: 28 March 2020 / Accepted: 26 May 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Polycystic ovary syndrome (PCOS) has been proposed to be associated with several mental health problems, including anxiety, depression, diminished sexual satisfaction, and lowered health-related quality of life, etc. A systematic review and meta-analysis of published literature was conducted comparing the mental health of women with and without PCOS. Ten English and Chinese databases were searched up to 12/31/2018. Random-effects models were introduced, and subgroup analysis, sensitivity test, and meta-regression were carried out to determine the source for heterogeneity among studies. Forty-six studies, including 30,989 participants (9265 women with PCOS and 25,638 controls), were qualified for review according to the inclusion criteria. Twentyeight studies reported depression symptoms, 22 studies were on anxiety, 16 studies showed quality of life (QoL) status, 12 studies were about sexual dysfunction, five on emotional distress, four on binge eating, and four on somatization. Women with PCOS reported significantly higher depression (SMD = 0.64; 95% CI 0.50–0.78), anxiety (SMD = 0.63; 95% CI 0.50–0.77), lower QoL (SMD = − 0.55; 95% CI −0.69 to −0.40), and not significant sexual dysfunction (SMD = − 0.24; 95% CI − 0.49 to 0.01). Studies from different countries, adopting various diagnosis criteria, using diverse instruments, as well as in different years, have reported heterogenetic results. Women with PCOS in China reported a larger effect size of depression and anxiety than patients from other countries. The results of this study have indicated that women with PCOS suffer from depression, anxiety, and experience a lower quality of life, whereas their sexual function is not distinct from that of healthy women. Psychological health care interventions for women with PCOS were addressed. Keywords Polycystic ovary syndrome . Depression . Anxiety . Quality of life . Sexual dysfunction . Meta-analysis
Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women in the childbearing age (Romanowski et al. 2015). International estimates have indicated that the prevalence rates of PCOS are 10–20%, and diagnosis is frequently performed during adolescence (Asgharnia et al. 2011; Vijaya and Bharatwaj 2014). The Rotterdam criteria for PCOS are those who met two of the following three: (1) oligo- and/or anovulation; (2) clinical and/or biochemical signs of hyperandrogenism; (3) polycystic * Celia Hoi Yan Chan [email protected] 1
Department of Social Work and Social Administration, The University of Hong Kong, Pokfulam Road, Hong Kong, China
2
The Jockey Club Tower, Centennial Campus, The University of Hong Kong, Room 543, 5/F, Pokfulam Road, Hong Kong, China
ovaries by ultrasound (The Rott
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