Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis
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REVIEW
Open Access
Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis Jun Z Qin1, Li H Pang2*, Mu J Li3*, Xiao J Fan1, Ru D Huang1 and Hong Y Chen1
Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined. Methods: Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University. Results: A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49–4.74), PIH (OR3.43; 95% CI: 2.49–4.74), preeclampsia (OR2.17; 95% CI: 1.91–2.46), preterm birth (OR1.93; 95%CI: 1.45–2.57), caesarean section (OR 1.74; 95% CI: 1.38–2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD −0.11g; 95%CI: -0.19 – -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40–3.85) compared to controls. Conclusions: Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications. Keywords: Polycystic ovary syndrome, Pregnancy and neonatal complications, Meta-analysis
Background Polycystic ovary syndrome (PCOS) is a common and complicated female endocrinopathy that estimated prevalence varies from 3%–20% depending on the diagnostic criteria used [1]. The most common features of PCOS are abnormal ovulation, clinical or laboratory indices of increased androgen levels, and polycystic ovaries on ultrasonography. Clinical manifestations of PCOS are menstrual irregularity (oligomenorrhea or amenorrhea), hirsutism, persistent acne, androgen dependent alopecia, abdominal obesity, * Correspondence: [email protected]; [email protected] 2 Department of Prenatal Diagnosis Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China 3 Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China Full list of author info
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