The Eukaryotic Replisome: a Guide to Protein Structure and Function
Successful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, mak
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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany
ASSISTANT EDITOR P.J. QUINN, King’s College London, London, U.K. Recent Volumes in this Series Volume 33 Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker Volume 34 Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller Volume 35 Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton Volume 36 Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan Volume 37 Membrane Dynamics and Domains Edited by P.J. Quinn Volume 38 Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz Volume 39 Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas Volume 40 Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda Volume 41 Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta Volume 42 Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris Volume 43 Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel Volume 44 Peroxiredoxin Systems Edited by Leopold Flohd J. Robin Harris Volume 45 Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini Volume 46 Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and MarkusWyss Volume 47 Molecular Mechanisms of Parasite Invasion Edited by Barbara A. Burleigh and Dominique Soldati-Favre Volume 48 The Coronin Family of Proteins Edited by Christoph S. Clemen, Ludwig Eichinger and Vasily Rybakin Volume 49 Lipids in Health and Disease Edited by Peter J. Quinn and XiaoyuanWang Volume 50 Genome Stability and Human Diseases Edited by Heinz Peter Nasheuer Volume 51 Cholesterol Binding and Cholesterol Transport Proteins Edited by J. Robin Harris Volume 52 A Handbook of Transcription Factors Edited by T.R. Hughes For further volumes: http://www.springer.com/series/6515
Stuart MacNeill Editor
The Eukaryotic Replisome: A Guide to Protein Structure and Function
Editor Stuart MacNeill School of Biology University of St Andrews St Andrews, Fife, UK
ISSN 0306-0225 ISBN 978-94-007-4571-1 ISBN 978-94-007-4572-8 (eBook) DOI 10.1007/978-94-007-4572-8 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012945769 © Springer Science+Business Media Dordrecht 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi
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