The G Protein-Coupled Receptors Handbook
G protein-coupled receptors (GPCRs) are involved in many processes in the human body relevant to health and disease, and consequently are the targets of approximately 70% of pharmacological therapeutics and a major source of new drug candidates. In The G
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ontemporary linical euroscience
Series Editors: Ralph Lydic and Helen A. Baghdoyan
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Contemporary Clinical Neuroscience
THE G PROTEIN-COUPLED RECEPTORS HANDBOOK Edited by
LAKSHMI A. DEVI, PhD Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY
Foreword by
Andreas Engel, PhD M.E. Müller Institute, Biozentrum, University of Basel, Basel, Switzerland
Krzysztof Palczewski, PhD Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA
© 2005 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. Production Editor: Tracy Catanese Cover design by Patricia F. Cleary Cover illustration: Atomic force microscopy (AFM) of native mouse disk membranes imaged in buffer solution (Fotiadis, D., et al. [2003] Nature 421:127). Based on the AFM data and crystal structure of rhodopsin (Palczewski, K., et al. (2000). Science 289, 739), a 3-D model for the packing arrangement of rhodopsin molecules within the paracrystalline arrays in native disk membranes as computed and 6 rhodopsin molecules are displayed (Liang, Y. et al. [2003] J Biol Chem 278:21,655). Artwork created by and courtesy of Kris Palczewski, Andreas Engel, and Slawek Filipek. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected] or visit our website at www.humanapress.com The opinions expressed herein
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