The Hereditary Basis of Rheumatic Diseases

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic stud

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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: Chemokine Biology: Basic Research and Clinical Appliation, Volume II: Pathophysiology of Chemokines, K. Neote, G.L. Letts, B. Moser (Editors), 2006 Endothelial Dysfunction and Inflammation, A. Graham (Editor), 2006 In vivo Models of Inflammation, 2nd edition, C. S. Stevenson, D. W. Morgan, L. A. Marshall (Editors), 2006 Lymphocyte Trafficking in Health and Disease, R. Badolato, S. Sozzani (Editors), 2006 The Resolution of Inflammation, A.G. Rossi, D.A. Sawatzky (Editors), 2006 (Already published titles see last page.)

The Hereditary Basis of Rheumatic Diseases

Rikard Holmdahl Editor

Birkhäuser Verlag Basel · Boston · Berlin

Editor Rikard Holmdahl Section for Medical Inflammation Research Department of Cell and Molecular Biology Lund University Solvegatan 19, I11 BMC S-221 84 Lund Sweden

Library of Congress Cataloging-in-Publication Data The hereditary basis of rheumatic diseases / Rikard Holmdahl, editor. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN-13: 978-3-7643-7201-9 (alk. paper) ISBN-10: 3-7643-7201-X (alk. paper) ISBN-13: 978-3-7643-7419-8 (e-ISBN) ISBN-10: 3-7643-7419-5 (e-ISBN) 1. Rheumatism--Genetic aspects. I. Holmdahl, Rikard, 1953- II. PIR (Series) RC927.H47 2006 616.7’23042--dc22 2006040762 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

ISBN-10: 3-7643-7201-X Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7201-9 Birkhäuser Verlag, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2006 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ∞ Cover design: Markus Etterich, Basel Cover illustratio