The Impact of Material Nanotopography on Cell Functions and Filopodia Extension: Experiments and Modeling
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The Impact of Material Nanotopography on Cell Functions and Filopodia Extension: Experiments and Modeling Lei Yang 1, Qunyang Li1, 3, Viswanath Chinthapenta1, Amy Liang1, Brian W. Sheldon 1 and Thomas J. Webster 1,2 1 Division of Engineering, Brown University, Providence, RI 02912, USA 2 Department of Orthopaedics, Brown University, Providence, RI 02912, USA 3 Department of Mechanical Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
ABSTRACT Exploring the cell-material interface is an emerging area of great interest in biomaterial science. Specifically, creating nanostructured surface interfaces to improve biomaterial efficacy is one of these key focus topics. As an example, an increasing number of studies have demonstrated the positive role nanostructured surfaces can have towards promoting various cell functions. However, the relevant mechanism behind this improvement in biological interactions at the cell-implant interface is not well understood. For this reason, here, osteoblast (bone forming cells) and fibroblast (fibrous, soft tissue forming cells) functions (including adhesion and proliferation) on two carefully fabricated diamond films with dramatically different topographies were tested. The results revealed greater cell responses on nanocrystalline diamond (grain sizes
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