The Inhibitors of the Fibrinolytic System
Studies in transgenic mice deficient in plasminoge, tissue-type plasminogen activator (tPA), urinary-type plasminogen activator (uPA), or plasminogen activator inhibitor type-1 (PAI-1) have confirmed the major role of the PA system in fibrin clot surveill
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Fibrinolytics and Antifibrinolytics Contributors F. Bachmann, D.C. Berridge, C. Bode, H . Bounameaux, FJ. Castellino, X H . Chesebro, A.C. Chiu, D. Collen, G. J. del Zoppo, W. Dietrich, P. Donner, J.J. Emeis, L. Flohe, V. Fuster, R. Gallo, W.A. Günzler, V. Gurewich, E. Haber, S.B. Hawley, R. Hayes, T. Herren, J.L. Hoover-Plow, J. Horrow, T. Kooistra, E.K.O. Kruithof, H.R. Lijnen, V.J. Marder, L . A . Miles, K. Peter, E.F. Plow, V.A. Ploplis, A . Redlitz, M.S. Runge, C M . Samama, M . M . Samama, A . A . Sasahara, W.-D. Schleunig, G.V.R.K. Sharma, O. Taby, E.J. Topol, M . Verstraete, S. Xue
Editor:
F. Bachmann
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Springer
Professor emeritus F. B A C H M A N N
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With 47 Figures and 50 Tables ISBN 978-3-642-63029-3 ISBN 978-3-642-56637-0 (eBook) DOI 10.1007/978-3-642-56637-0 Library of Congress Cataloging-in-Publication Data Fibrinolytics and antifibrinolytics / contributors, F. Bachmann . . . [et al.]; editor, Fedor Bachmann, p. cm. - (Handbook of experimental pharmacology; v. 146) Includes bibliographical references and index. 1. Thrombolytic therapy. 2. Fibrinolytic agents. 3. Fibrinolysis. 4. Antifibrinolytic agents. I. Bachmann, Fedor. II. Series. [DNLM: 1. Fibrinolytic Agents. 2. Antifibrinolytic Agents. Q V 190 F4431 2001] QP905 .H3 vol. 146 [RC694.3] 615'.ls - dc21 [6i5'.7i8] 00-059471 This work is subject to copyright. A l l rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for Prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 2001 Originally published by Springer-Verlag Berlin Heidelberg New York in 2001 Softcover reprint of the hardcover 1st edition 2001 The use of general descriptive names, registered names, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: design & production GmbH, Heidelberg Typesetting: Best-set Typesetter Ltd., Hong Kong
Preface
In 1978, Fritz Markwardt edited Fibrinolytics and Antifibrinolytics, vol. 46 of
the Handbook of Experimental Pharmacology series. Since then tremendous strides have been made in our und
