The metabolic syndrome in pregnancy and its association with child telomere length
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The metabolic syndrome in pregnancy and its association with child telomere length Dale McAninch 1,2 & Tina Bianco-Miotto 1,3 & Kathy L. Gatford 1,2 & Shalem Y. Leemaqz 1,2,4 & Prabha H. Andraweera 1,2 & Amy Garrett 1,2 & Michelle D. Plummer 1,2 & Gus A. Dekker 1,5 & Claire T. Roberts 1,2,4 Lisa G. Smithers 1,6 & Jessica A. Grieger 1,2
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Received: 9 March 2020 / Accepted: 24 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Aims/hypothesis The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. Methods The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14–16 weeks’ gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children’s saliva collected at 10 years of age. Results In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference −0.36 [95% CI −0.74, 0.01]). Height- and weight-for-age, and BMI z scores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy. Conclusions/interpretation Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood. Keywords Cardiovascular . Children . Developmental programming . Maternal . Metabolic syndrome . Obesity . Offspring . Pregnancy . Telomere length Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-020-05242-0) contains peer-reviewed but unedited supplementary material, which is available to authorised users. * Jessica A. Grieger [email protected] 1
Robinson Research Institute, University of Adelaide, North Adelaide, SA 5005, Australia
2
Adelaide Medical School, University of Adelaide, Adelaide, Australia
3
Waite Research Institute, School of Agriculture, Food and Wine, University of Adelaide, Adelaide, SA, Australia
4
College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia
5
Women and Children’s Division, Lyell McEwin Hospital, University of Adelaide, Adelaide, SA, Australia
6
School of Public Health, University of Adelaide, Ade
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