The mRNA Metabolism in Human Disease
The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly
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Luísa Romão Editor
The mRNA Metabolism in Human Disease
Advances in Experimental Medicine and Biology Volume 1157 Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Children’s Medical Center Hospital, Tehran University of Medical Sciences Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Luísa Romão Editor
The mRNA Metabolism in Human Disease
Editor Luísa Romão Department of Human Genetics National Institute of Health Doutor Ricardo Jorge Lisboa, Portugal Faculty of Sciences, BioISI – Biosystems & Integrative Sciences Institute University of Lisbon Lisboa, Portugal
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-19965-4 ISBN 978-3-030-19966-1 (eBook) https://doi.org/10.1007/978-3-030-19966-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease���������������������������������� 1 Peter Jordan, Vânia Gonçalves, Sara Fernandes, Tânia Marques, Marcelo Pereira, and Margarida Gama-Carvalho 2 The Diverse Roles of RNA-Binding Proteins in Glioma Development ���������������������������������������������������������������� 29 Mitzli X. Velasco, Adam Kosti, Luiz O. F. Penalva, and Greco Hernández 3 Nonsense-Mediated mRNA Decay in Development, Stress and Cancer���������������������������������������������������������
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