Cardiac Energy Metabolism in Health and Disease

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and carbohydrates to some exten

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Gary D. Lopaschuk Naranjan S. Dhalla Editors

Cardiac Energy Metabolism in Health and Disease

Advances in Biochemistry in Health and Disease Series Editor: Naranjan S. Dhalla Winnipeg, Manitoba, Canada

Volume 1: S. K. Cheema, (ed), Biochemistry of Atherosclerosis Volume 2: S. W. Schaffer and M-Saadeh Suleiman, (eds), Mitochondria: The Dynamic Organelle Volume 3: A. K. Srivastava and M. B. Anand-Srivastava, (eds), Signal Transduction in the Cardiovascular System in Health and Disease Volume 4: B. Ostadal and N. S. Dhalla, (eds), Cardiac Adaptations-Molecular Mechanisms Volume 5: B. I. Jugdutt and N. S. Dhalla (eds), Cardiac Remodeling-Molecular Mechanisms Volume 6: Jawahar L. Mehta and N. S. Dhalla (eds), Biochemical Basis and Therapeutic Implications of Angiogenesis Volume 7: S. Chakraborti and N. S. Dhalla (eds), Proteases in Health and Disease Volume 8: N. S. Dhalla and S. Chakraborti (eds), Role of Proteases in Cellular Dysfunction Volume 9: B. Turan and N. S. Dhalla (eds), Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms Volume 10: P. S. Tappia and N. S. Dhalla (eds.), Phospholipases in Health and Disease Volume 11: G.D. Lopaschuk and N.S. Dhalla (eds), Cardiac Energy Metabolism in Health and Disease

For further volumes: http://www.springer.com/series/7064

Gary D. Lopaschuk • Naranjan S. Dhalla Editors

Cardiac Energy Metabolism in Health and Disease

Editors Gary D. Lopaschuk Department of Pediatrics University of Alberta Edmonton, AB, Canada

Naranjan S. Dhalla Institute of Cardiovascular Sciences St. Boniface Hospital Research University of Manitoba Winnipeg, MB, Canada

ISBN 978-1-4939-1226-1 ISBN 978-1-4939-1227-8 (eBook) DOI 10.1007/978-1-4939-1227-8 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014945756 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does no