The Synthesis of rGO/Ni/Co Composite and Electrochemical Determination of Dopamine
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The Synthesis of rGO/Ni/Co Composite and Electrochemical Determination of Dopamine Qian He1 · Xinyuan Kang1 · Fengping Fu1 · Miao Ren1 · Fang Liao1 Received: 19 December 2019 / Accepted: 31 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this paper, a composite material (rGO/Ni/Co) was synthesized by a hydrothermal method and high temperature annealing, and used for the determination of dopamine (DA). Surface morphology and structure of the rGO/Ni/Co were characterized by Scanning electron microscope (SEM), Transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD). The effects of different pH, scanning rate and interfering substances on the electrochemical properties of dopamine were discussed. The electrochemical test results show that the rGO/Ni/Co/GCE electrode has excellent electrocatalytic activity for dopamine. Under the optimized conditions, the linear range of detection is 10 µmol/L-2250 µmol/L (r = 0.99837), the detection limit is 0.119 µmol/L, and the signal-to-noise ratio is 3. The interference test showed, that most of the ions did not show obvious influence on the detection of DA, indicating that the prepared electrode has selectivity for the detection of DA. Moreover, the composite has good magnetic properties and is convenient for sample separation and recovery. Keywords Dopamine · Electrocatalytic · Reduced graphene oxide · Ni · Co
1 Introduction Dopamine (DA) is noted to be an important neurotransmitter occurring in the human body (brain and kidney) and is widely distributed in the central nervous system of mammals. It plays a vital role in the central nervous system, kidneys, hormones and cardiovascular system [1, 2]. For Qian He and Xinyuan Kang have contributed equally. * Fang Liao [email protected] Qian He [email protected] Xinyuan Kang [email protected] Fengping Fu [email protected] Miao Ren [email protected] 1
Chemical Synthesis and Pollution Control, Key Laboratory of Sichuan Province, School of Chemistry and Chemical Industry, China West Normal University, Nanchong 637002, China
example, dopamine controls the excretion of sodium in the kidneys and the production of urine. So, abnormal DA content can lead to some brain diseases. When dopamine is deficient, it can lead to Parkinson’s disease, schizophrenia and epilepsy [3, 4]. High levels of DA are associated with multiple functional disorders. It is also related to some diseases and drug addiction [5, 6]. Diagnosis of these diseases necessitates very accurate measurements of DA in biological samples. Therefore, finding a reliable dopamine content detection method is of great significance for the early diagnosis and prevention of such diseases [7]. At present, many dopamine detection technologies have been developed and implemented. As far as we know, there are ultraviolet visible spectrophotometry, capillary electrophoresis, fluorescence spectrophotometry, chemiluminescence and high performance liquid chromatography [8–12]. Despite bei
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