The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan
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ORIGINAL ARTICLE—LIVER, PANCREAS, AND BILIARY TRACT
The transition in the etiologies of hepatocellular carcinomacomplicated liver cirrhosis in a nationwide survey of Japan Hirayuki Enomoto1 • Yoshiyuki Ueno2 • Yoichi Hiasa3 • Hiroki Nishikawa1,4 • Shuhei Hige5 • Yasuhiro Takikawa6 • Makiko Taniai7 • Toru Ishikawa8 • Kohichiroh Yasui9 • Akinobu Takaki10 • Koichi Takaguchi11 • Akio Ido12 • Masayuki Kurosaki13 • Tatsuya Kanto14 • Shuhei Nishiguchi1,15 • Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
Received: 26 August 2020 / Accepted: 31 October 2020 Ó The Author(s) 2020
Abstract Background We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC). Methods Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The changing trends in etiologies were assessed. We further analyzed the data from 29 hospitals that provided the Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00535-020-01748-x) contains supplementary material, which is available to authorized users.
annual number of newly identified HCC-complicated LC patients from 2008 to 2016 (N = 9362) without any missing years and assessed the transition in the real number of newly identified HCC-complicated LC cases. Results In the overall cohort, hepatitis C virus (HCV) infection (60.3%) and hepatitis B virus (HBV) infection (12.9%) were the leading and third-most common causes of HCC-complicated LC in Japan, respectively. HCV infection was found to be the leading cause throughout Japan. The rate of viral hepatitis-related HCC decreased from 85.3 to 64.4%. Among non-viral etiologies, notable increases were observed in nonalcoholic steatohepatitis (NASH)-related HCC (from 1.5 to 7.2%) and alcoholic liver disease (ALD)-related HCC (from 8.5 to 18.6%). Regarding the
& Shuhei Nishiguchi [email protected]
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Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
10
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
2
Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan
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Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan
3
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan
12
4
Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
13
Department of Hepatology, Sapporo Kosei General Hospital, Sapporo, Japan
Department of Gastroenterology and Hepatology,
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