The Use of PRF for Hard and Soft Tissue Grafting
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CLINICAL PERIODONTICS (P STATHOPOULOU, SECTION EDITOR)
The Use of PRF for Hard and Soft Tissue Grafting Theodoros Katsaros 1 & Panagiotis Dragonas 2
# Springer Nature Switzerland AG 2020
Abstract Purpose of Review The use of platelet-rich fibrin (PRF), a second-generation platelet concentrate, has gained popularity in the field of oral regenerative surgery. This review presents data from published clinical trials on outcomes from PRF application in regeneration of infrabony defects, implant site development, and mucogingival surgery. Recent Findings When PRF is used for regeneration of infrabony defects, minor improvements are noted in the clinical parameters that in the majority of the cases does not reach the level of statistical significance. The use of PRF appears to limit the dimensional changes of the alveolar ridge after tooth extraction when compared with sockets that are allowed to heal with no grafting. When combined with coronally advanced flaps (CAF) for root coverage, PRF shows a slight advantage over CAF alone. Summary Despite the adequate volume of publications in the field, the limitations of the existing studies highlight the need for high level of evidence to support the significant benefit of PRF in hard and soft tissue within the scope of periodontal and periimplant surgery. Keywords Platelet-rich fibrin . Bone grafting . Sinus augmentation . Alveolar ridge preservation . Infrabony defects . Mucogingival surgery
Introduction Different biomaterials have been utilized over the years in the field of periodontal regeneration. Regeneration is defined as the reproduction or reconstitution of a lost or injured part, in a manner similar or identical to its original form. This task is even more challenging when we refer to periodontal regeneration that requires the formation of new bone, cementum, and a functionally oriented periodontal ligament in a site where the original attachment apparatus was lost [1]. Several growth factors have been utilized by clinicians in an effort to enhance the healing potential following a surgical regenerative procedure. These growth factors target specific cells participating in different phases of wound healing with This article is part of the Topical Collection on Clinical Periodontics * Theodoros Katsaros [email protected] 1
Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, 801 Newton Rd., S447, Iowa City, IA 52242, USA
2
Department of Periodontics, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA
the ultimate goal of optimizing the final healing outcome. Their origin varies and can be classified as autogenic, allogenic, and xenogeneic [2–4]. One of the early reports of the use of concentrated autogenous growth factors in intra-oral bone grafting procedures is the use of platelet-rich plasma (PRP) by Dr. Marx and colleagues in 1998. The patients in this study underwent mandibular reconstruction of large defects that resulted from tumor resection. The authors demonstr
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