Preeclampsia Methods and Protocols
This volume presents the latest developments and techniques used to study the physiopathology, diagnosis, and treatment of pre-eclampsia. Written for clinicians, obstetricians, basic scientists, researchers, and students the chapters in this book provide
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Padma Murthi Cathy Vaillancourt Editors
Preeclampsia Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Preeclampsia Methods and Protocols
Edited by
Padma Murthi Monash Medical Centre, Monash University, Clayton, VIC, Australia
Cathy Vaillancourt INRS-Institut Armand-Frappier, Laval, QC, Canada
Editors Padma Murthi Monash Medical Centre Monash University Clayton, VIC, Australia
Cathy Vaillancourt INRS-Institut Armand-Frappier Laval, QC, Canada
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7497-9 ISBN 978-1-4939-7498-6 (eBook) https://doi.org/10.1007/978-1-4939-7498-6 Library of Congress Control Number: 2017957846 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover illustration: Human chorionic villi from the intervillous space © UMR-S 1139 INSERM, University of Paris Descartes; Pathophysiology and Pharmacotoxicology of the Human Placenta and Cellular and Molecular Imaging Facility, Inserm US 25, CNRS UMS 3612, Faculty of Pharmacy of Paris, 4 avenue de l’Observatoire. 75006 Paris, France Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Hippocrates wrote in one of his Aphorisms that “convulsions take place from either repletion or depletion.” He was then, the first to describe preeclampsia, and the sudden and unexpected appearance of maternal “grand-mal seizure” which occur when the disease progresses to eclampsia (from the Greek “lightning”) [1]
The aim of this volume on Preec
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