Thymus Transcriptome and Cell Biology
This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (t
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Thymus Transcriptome and Cell Biology
Thymus Transcriptome and Cell Biology
Geraldo A. Passos Editor
Thymus Transcriptome and Cell Biology
Editor Geraldo A. Passos Laboratory of Genetics and Molecular Biology Department of Basic and Oral Biology School of Dentistry of Ribeirão Preto University of São Paulo Ribeirão Preto, SP, Brazil Molecular Immunogenetics Group Department of Genetics Ribeirão Preto Medical School University of São Paulo Ribeirão Preto, SP, Brazil
ISBN 978-3-030-12039-9 ISBN 978-3-030-12040-5 (eBook) https://doi.org/10.1007/978-3-030-12040-5 Library of Congress Control Number: 2019935516 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
The importance of the thymus as the primary lymphoid organ responsible for the generation and selection of T lymphocytes is now obvious. Nevertheless, the thymus has long been a mysterious organ. It was not until 1961 that J. F. Miller showed in seminal studies that “the thymus at birth can be essential to life,” quickly followed by its role in immunological tolerance by skin grafting experiments in mice. It is always surprising that this key discovery for any immunologist, physician, or biologist did not happen sooner. The skepticism surrounding this discovery, from such eminent immunologists as Burnet, Medawar, or Mitchison, may also be astonishing, Sir Peter Medawar even going so far as to declare in 1963 “we will come to look at the presence of lymphocytes in the thymus as an evolutionary accident with little significance.” This controversy remains exemplary and instructive for our ways to get out of accepted dogmas. This was a “golden age” of immunology, the 1960s being particularly
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