Thyroid Cytopathology

Thyroid Cytopathology, the inaugural volume of the Essentials in Cytopathology Series, provides an overview to the examination and diagnosis of thyroid cytology specimens. Each concise desktop reference in the Essentials in Cytopathology Series is designe

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ESSENTIALS IN CYTOPATHOLOGY SERIES Dorothy L. Rosenthal, MD, FIAC, Series Editor

1. D.P. Clark and W.C. Faquin: Thyroid Cytopathology. 2005 ISBN 0-387-23304-0

Douglas P. Clark, MD Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland

William C. Faquin, MD, PhD Department of Pathology, Massachusetts General Hospital, and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

Thyroid Cytopathology With 116 Illustrations, 104 in Full Color

Foreword by Edmund S. Cibas, MD

Douglas P. Clark, MD Department of Pathology The Johns Hopkins Medical Institutions Baltimore, MD 21287 USA

William C. Faquin, MD, PhD Department of Pathology Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary Boston, MA 02114 USA

Series Editor: Dorothy L. Rosenthal, MD, FIAC Professor of Pathology, Oncology, and Gynecology and Obstetrics The Johns Hopkins Medical Institutions Director of Pathology The Johns Hopkins Bayview Medical Center Baltimore, MD 21287 USA

Library of Congress Cataloging-in-Publication Data Clark, Douglas P. Thyroid cytopathology / Douglas P. Clark, William C. Faquin. p. ; cm. – (Essentials in cytopathology series ; 1) Includes bibliographical references and index. ISBN 0-387-23304-0 (alk. paper) 1. Thyroid gland—Cytopathology. I. Faquin, William C. II. Title. III. Series. [DNLM: 1. Thyroid Nodule—diagnosis. 2. Thyroid Nodule—physiopathology. 3. Biopsy, Fine-Needle—methods. 4. Thyroid Gland—pathology. WK 270 C592t 2005] RC655.49.C56 2005 616.4¢407—dc22 2004062586 ISBN 0-387-23304-0

Printed on acid-free paper.

© 2005 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed in China. 9 8 7 6 5 4 3 2 1 springeronline.com

(BS/EVB) SPIN 10938645

Foreword

The evaluation of thyroid nodules by fine needle aspiration (FNA) is arguably the most challenging task in all of cytopathology. A cytologist must understand the clinical presentation of thyroid diseases, their defining histopathologic and cytopathologic features, and t