Time-trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change
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ORIGINAL PAPER
Time‑trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines Knirsch Walter1,2 · Schuler Stefanie Katharina1,2 · Christmann Martin1,2 · Weber Roland1,2 Received: 13 April 2020 / Accepted: 23 April 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose In 2007, antibiotic prophylaxis (AP) guidelines for infective endocarditis (IE) changed, but the possible influence on the annual incidences of pediatric IE is unclear. Methods We studied the clinical and epidemiologic impact of AP change by comparing two time periods before and after change of AP guidelines in a tertiary care center as referral center for a total population of more than 4,500,000 inhabitants. Results After change of AP guidelines, twenty-five patients were diagnosed for IE at a median age of 6.9 years (range 0.1–19.4, female 48%). Modified Duke criteria were fulfilled for definite (12/25; 48%), or probable IE (13/25; 52%). The frequency of IE (cases per 1000 hospitalized patients) increased from 0.37% (1995–2005) to 0.59% (2006–2017) [p = 0.152], the annual incidence of IE (cases per 1000 CHD patients,
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