Tofacitinib
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Tofacitinib Herpes-simplex encephalitis: case report
A 62-year-old man developed Herpes simplex virus encephalitis during treatment with tofacitinib for psoriasis and rheumatoid arthritis. The man, who had psoriasis and rheumatoid arthritis had been receiving tofacitinib [dosage and route not stated]. His medical history was significant for Herpes simplex encephalitis 19 years before and Hodgkin lymphoma. He was hospitalised for disorientation symptoms preceded by fever. A lumbar puncture showed a slightly increase in protein and WBC count. A PCR revealed positivity for Herpes simplex virus-1 encephalitis which was considered secondary to tofacitinib use [duration of treatment to reaction onset not stated]. Therefore, the man’s treatment with tofacitinib was discontinued. He started treatment with aciclovir with satisfactory evolution. Following discharge, he received acyclovir and pimecrolimus. Lapena Motilva J, et al. Herpes simplex encephalitis in a patient treated with tofacitinib. European Journal of Neurology 27 (Suppl. 1): 995, May 2020 [abstract]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
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Reactions 29 Aug 2020 No. 1819
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