Topotecan
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Pulmonary toxicity: case report A retrospective analysis identified a 60-year-old man who developed pulmonary toxicity while receiving topotecan for small cell lung cancer. The man, who had interstitial lung disease associated with lung cancer, started second-line treatment with topotecan 1 mg/m2 (from day 1 to day 5, every 3 weeks) [route not stated]. After two cycles, a CT scan showed worsening ground glass opacity. Topotecan was withdrawn and corticosteroids were not required [outcome not stated]. Author comment: "Pulmonary toxicity was observed in one case . . ." Suzuki H, et al. Effect of topotecan as second-line chemotherapy for small cell lung cancer patients with interstitial lung disease. Journal of Chemotherapy 23: 803078008 367-70, No. 6, Dec 2011 - Japan
0114-9954/10/1422-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 6 Oct 2012 No. 1422
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