Toxicology of Metals Biochemical Aspects

The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in

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G.V.R. Born, London P. Cuatrecasas, Ann Arbor, MI D. Ganten, Berlin H. Herken, Berlin K.L. Melman, Stanford, CA

Toxicology of Metals Biochemical Aspects Contributors N. Ballatori, M.G. Cherian, D.C. Dawson, M. Delnomdedieu P. Druet, B.R Fisher, P. Goering, RA. Goyer, S. Himeno N. Imura, E.H. leffrey, M.M. lones, l.H.R Kagi, S. Kawanishi C.D. Klaassen, l. Koropatnick, l.S. Lazo, M.E.I. Leibbrandt K. Miura, A. Naganuma, E.l. O'Flaherty, L. Pelletier T.G. Rossman, S. Silver, M. Styblo, D.M. Templeton, D.l. Thomas M.P. Waalkes, M. Walderhaug, l.S. Woods, l. Zeng

Editors

Robert A. Goyer and M. George Cheri an

Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest

ROBERT A. GOYER, M.D. Professor Emeritus Department of Pathology University of Western Ontario Health Sciences Centre London, Ontario, Canada N6A SCI M. GEORGE CHERIAN, Ph.D. Professor Department of Pathology University of Western Ontario Health Sciences Centre London, Ontario, Canada N6A SCI

With 37 Figures and 17 Tables ISBN-13:978-3-642-79164-2 e-ISBN-13:978-3-642-79162-8 001: 10.1007/978-3-642-79162-8

Library of Congress Cataloging·in·Publication Data. Toxicology of metals: biochemical aspects/contributors N. Ballatori ... [et al.]; editors, Robert A. Goyer and M. George Cherian. p. cm. - (Handbook of experimental pharmacology; v. 115) Includes bibliographical references and index. ISBN-13:978-3-642-79 164-2 1. Metals - Toxicology. I. Ballatori, N. II. Goyer, Robert. III. Cherian, M. George, 1941- . IV. Series. [DNLM: 1. Metals - toxicity. 2. Maximum Permissible Exposure Level. WI HA51L v. 115 1995/QV 290 T755 1995] QP905.H3 vol. 115 [RA1231.M52] 615'. I s-dc20 [615.9'253] DNLMIDL-C for Library of Congress 94-26484 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Vedag. Violations are liable for prosecution under the German Copyright Law.

© Springer-Vedag Berlin Heidelberg 1995 Softcover reprint of the hardcover 1st edition 1995 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Best-set Typesetter Ltd., Hong Kong SPIN: 10096516

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