Tramadol has lower rate of abuse than other opioid analgesics
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Tramadol has lower rate of abuse than other opioid analgesics Tramadol appears to be associated with a lower rate of nonmedical use (NMU) than other opioid analgesics, according to findings of an Avenue Therapeutics-funded US study published in Drug Safety. NMU of tramadol versus other opioid analgesics was evaluated during the previous 30 days in US adults assessed for substance abuse disorder and treatment between 2010 and 2018, using the National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO) Addiction Severity Index—Multimedia Version (ASI-MV) clinical assessment tool. Overall, NMU of at least one prescription opioid was reported in 22.6% of the 125 048 ASI-MV assessments during the study period. NMU was less frequently reported with tramadol (7.2%) and morphine (8.1%) than with oxycodone (46.5%) and hydrocodone (43.2%). The prevalence of tramadol NMU in the previous 30 days was significantly lower than that of morphine, oxycodone and hydrocodone. The rate of snorting the medication was 4–7 times lower for tramadol than for the other opioids, and the rate of injecting the medication was 14–34 times lower for tramadol than for morphine and oxycodone. Tramadol was prescribed to the patient in most cases of NMU, but other opioid analgesics were more likely to be obtained from dealers, family or friends. "Understanding abuse potential of different analgesic therapies is important for providers and patients as they balance the benefits of pain therapy with the potential risks associated with NMU, particularly when used via non-oral routes of administration. The most recent epidemiological evidence, including findings from this study, support earlier evaluations by the WHO and DEA* that concluded that tramadol has a low potential for abuse and is appropriately designated as a Schedule IV drug," concluded the authors. * Drug Enforcement Agency Green JL, et al. Real-World Data on Nonmedical Use of Tramadol from Patients Evaluated for Substance Abuse Treatment in the NAVIPPRO Addiction Severity Index 803516440 Multimedia Version (ASI-MV) Network Drug Safety : 11 Nov 2020. Available from: URL: https://doi.org/10.1007/s40264-020-01012-4
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Reactions 21 Nov 2020 No. 1831
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