Transactions on Computational Systems Biology VI

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Corrado Priami Gordon Plotkin (Eds.)

Transactions on Computational Systems Biology VI

13

Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Editor-in-Chief Corrado Priami The Microsoft Research - University of Trento Centre for Computational and Systems Biology Piazza Manci, 17, 38050 Povo (TN), Italy E-mail: [email protected] Volume Editor Gordon Plotkin The University of Edinburgh Division of Informatics Mayfield Road, Edinburgh EH9 3JZ, UK E-mail: [email protected]

Library of Congress Control Number: 2006935913

CR Subject Classification (1998): J.3, F.1, F.4, I.6 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

1861-2075 3-540-45779-8 Springer Berlin Heidelberg New York 978-3-540-45779-4 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 11880646 06/3142 543210

Preface

This issue of Transactions on Computational Systems Biology contains a fullyrefereed selection of papers from the Fourth International Conference on Computational Methods in Systems Biology, held in Edinburgh, Scotland, April 3–5, 2005. I would like to thank both the referees for all their hard work and also the CMSB 2005 programme committee for their help in choosing which papers to invite for submission. June 2006

Gordon Plotkin Program Chair CMSB 2005

LNCS Transactions on Computational Systems Biology – Editorial Board

Corrado Priami, Editor-in-chief Charles Auffray Matthew Bellgard Soren Brunak Luca Cardelli Zhu Chen Vincent Danos Eytan Domany Walter Fontana Takashi Gojobori Martijn A. Huynen Marta Kwiatkowska Doron Lancet Pedro Mendes Bud Mishra Satoru Miayano Denis Noble Yi Pan Alberto Policriti Magali Roux-Rouquie Vincent Schachter Adelinde Uhrmacher Alfonso Valencia

University of Trento, Italy Genexpress, CNRS and Pierre & Marie Curie University, France Murdoch University, Australia Technical University of