Fuzzy Systems in Bioinformatics and Computational Biology

Biological systems are inherently stochastic and uncertain. Thus, research in bioinformatics, biomedical engineering and  computational biology has to deal with a large amount of uncertainties. Fuzzy logic has shown to be a powerful tool in capturing

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Studies in Fuzziness and Soft Computing, Volume 242 Editor-in-Chief Prof. Janusz Kacprzyk Systems Research Institute Polish Academy of Sciences ul. Newelska 6 01-447 Warsaw Poland E-mail: [email protected] Further volumes of this series can be found on our homepage: springer.com Vol. 226. Bhanu Prasad (Ed.) Soft Computing Applications in Industry, 2008 ISBN 978-3-540-77464-8

Vol. 234. Eyal Kolman, Michael Margaliot Knowledge-Based Neurocomputing: A Fuzzy Logic Approach, 2009 ISBN 978-3-540-88076-9

Vol. 227. Eugene Roventa, Tiberiu Spircu Management of Knowledge Imperfection in Building Intelligent Systems, 2008 ISBN 978-3-540-77462-4

Vol. 235. Kofi Kissi Dompere Fuzzy Rationality, 2009 ISBN 978-3-540-88082-0

Vol. 228. Adam Kasperski Discrete Optimization with Interval Data, 2008 ISBN 978-3-540-78483-8

Vol. 236. Kofi Kissi Dompere Epistemic Foundations of Fuzziness, 2009 ISBN 978-3-540-88084-4

Vol. 229. Sadaaki Miyamoto, Hidetomo Ichihashi, Katsuhiro Honda Algorithms for Fuzzy Clustering, 2008 ISBN 978-3-540-78736-5 Vol. 230. Bhanu Prasad (Ed.) Soft Computing Applications in Business, 2008 ISBN 978-3-540-79004-4 Vol. 231. Michal Baczynski, Balasubramaniam Jayaram Fuzzy Implications, 2008 ISBN 978-3-540-69080-1 Vol. 232. Eduardo Massad, Neli Regina Siqueira Ortega, Laécio Carvalho de Barros, Claudio José Struchiner Fuzzy Logic in Action: Applications in Epidemiology and Beyond, 2008 ISBN 978-3-540-69092-4 Vol. 233. Cengiz Kahraman (Ed.) Fuzzy Engineering Economics with Applications, 2008 ISBN 978-3-540-70809-4

Vol. 237. Kofi Kissi Dompere Fuzziness and Approximate Reasoning, 2009 ISBN 978-3-540-88086-8 Vol. 238. Atanu Sengupta, Tapan Kumar Pal Fuzzy Preference Ordering of Interval Numbers in Decision Problems, 2009 ISBN 978-3-540-89914-3 Vol. 239. Baoding Liu Theory and Practice of Uncertain Programming, 2009 ISBN 978-3-540-89483-4 vol. 240. Asli Celikyilmaz, I. Burhan Türksen Modeling Uncertainty with Fuzzy Logic, 2009 ISBN 978-3-540-89923-5 vol. 241. Jacek Kluska Analytical Methods in Fuzzy Modeling and Control, 2009 ISBN 978-3-540-89926-6 Vol. 242. Yaochu Jin, Lipo Wang Fuzzy Systems in Bioinformatics and Computational Biology, 2009 ISBN 978-3-540-89967-9

Yaochu Jin and Lipo Wang

Fuzzy Systems in Bioinformatics and Computational Biology

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Editors Dr. Yaochu Jin Honda Research Institute Europe GmbH Carl-Legien-Str. 30 63073 Offenbach Germany E-Mail: [email protected] Prof. Dr. Lipo Wang Nanyang Technological University School of Electrical & Electronic Engineering 50 Nanyang Avenue Singapore 639798 E-Mail: [email protected]

ISBN 978-3-540-89967-9

e-ISBN 978-3-540-89968-6

DOI 10.1007/978-3-540-89968-6 Studies in Fuzziness and Soft Computing

ISSN 1434-9922

Library of Congress Control Number: 2008942029 c 2009 Springer-Verlag Berlin Heidelberg  This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm o