Transforming the practice of medicine through team science
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(2020) 18:104
STUDY PROTOCOL
Open Access
Transforming the practice of medicine through team science Jason H. Pitzen1, Heidi L. Dieter2, Darren L. Gronseth2, Amber K. Dahl2, Venessa L. Boyle3, Tharana Maran3, C. Michel Harper Jr4 and Gregory J. Gores5*
Abstract Background: The translation of biomedical research discoveries into clinical practice is marked by extended timelines (averaging 17 years) and multiple sequential process steps. However, even after a drug, device, diagnostic tool or unique therapeutic procedure successfully navigates through clinical testing to approval, real barriers remain in applying and scaling the innovation in practice. Methods: Mayo Clinic initiated the Transform the Practice programme to facilitate multidisciplinary team and convergence science to continuously reinvent solutions to address unmet patient needs and accelerate the application of next-generation healthcare solutions. During a 5-year period, 24 programme teams received financial resources, barrier-removing engagement from clinical and research leadership, and enhanced administrative support, including dedicated project managers. Results: The approach created value in facilitating consistent progress toward project objectives and resulted in multiple publications, new extramural funding sources, and implementation of new tests and services into the clinical practice. This report describes the concentrated institutional effort to accelerate the discovery–translation– application continuum in an academic medical centre and highlights successful applications and persistent obstacles. Conclusions: The Transform the Practice approach is effective in moving high-potential research discoveries closer to implementation in the clinical practice. Its concepts, including the application of structured project management methodology, may be quickly integrated to shorten an organisation’s time to implementing its most important discoveries. Keywords: Diffusion of innovation, Organisational innovation, Translational medical research
Background Investment in medical and health research and development in the United States reached $171.8 billion in 2016 [1], roughly 1% of the United States gross domestic product [2]. Although this sum corresponds to more than 45% of research and development spending by * Correspondence: [email protected] 5 Division of Gastroenterology and Hepatology and Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States of America Full list of author information is available at the end of the article
businesses in all industries [3], the average lag time from a biomedical research discovery to its translation into the clinical practice is 17 years [4, 5]. Hanney et al. outline the challenging nature of measuring this lag time and assert that the duration is likely even longer if standardised time points from basic research to health benefits are employed [6]. Such a prolonged time to market, which would
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