Transgenic and Knockout Models of Neuropsychiatric Disorders

Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when suc

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Series Editors: Ralph Lydic and Helen A. Baghdoyan

Transgenic and Knockout Models of Neuropsychiatric Disorders, edited by Gene S. Fisch and Jonathan Flint, 2006 The Orexin/Hypocretin System: Physiology and Pathophysiology, edited by Seiji Nishino and Takeshi Sakurai, 2006 The G Protein-Coupled Receptors Handbook, edited by Lakshmi A. Devi, 2005 Attention Deficit Hyperactivity Disorder: From Genes to Patients, edited by David Gozal and Dennis L. Molfese, 2005 Genetics and Genomics of Neurobehavioral Disorders, edited by Gene S. Fisch, 2003 Sedation and Analgesia for Diagnostic and Therapeutic Procedures, edited by Shobha Malviya, Norah N. Naughton, and Kevin K. Tremper, 2003 Neural Mechanisms of Anesthesia, edited by Joseph F. Antognini, Earl E. Carstens, and Douglas E. Raines, 2002 Glutamate and Addiction, edited by Barbara Herman, 2002 Molecular Mechanisms of Neurodegenerative Diseases, edited by MarieFrançoise Chesselet, 2000

Contemporary Clinical Neuroscience

TRANSGENIC AND KNOCKOUT MODELS OF NEUROPSYCHIATRIC DISORDERS Edited by

GENE S. FISCH, PhD Department of Statistics, Yeshiva University and Department of Psychology, CUNY/Lehman College New York, NY

JONATHAN F LINT, MD, MRCPsych Wellcome Trust Centre for Human Genetics and Department of Psychiatry, University of Oxford Oxford, UK

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Production Editor: Melissa Caravella Cover design by Patricia F. Cleary Cover Illustration: From Fig. 2 in Chapter 7, "How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?" by Simon E. Fisher. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected]; or visit our Website: www.humanapress.com The opinions expressed herein are the views of the authors and may not necessarily reflect the official policy of the National Institute on Drug Abuse or any other parts of the US Department of Health and Human Services. The US Government does not endor