Trastuzumab

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Cardiotoxicity: 26 case reports Twenty-six women with breast cancer developed cardiotoxicity during treatment with trastuzumab [ages not clearly stated; routes, dosages, durations of treatment to reactions onset and outcomes not stated]. Some of the women had a history of cardiovascular disease and/or obesity. Nineteen women with early breast cancer and six women with advanced breast cancer developed asymptomatic cardiotoxicity, defined as an absolute drop of at least 10% with a final left ventricular ejection fraction