Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective co
- PDF / 1,103,998 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 113 Downloads / 271 Views
RESEARCH ARTICLE
Open Access
Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13–01) Yun-Gyoo Lee1†, Eun Joo Kang2†, Bhumsuk Keam3* , Jin-Hyuk Choi4, Jin-Soo Kim5, Keon Uk Park6, Kyoung Eun Lee7, Jung Hye Kwon8, Keun-Wook Lee9, Min Kyoung Kim10, Hee Kyung Ahn11, Seong Hoon Shin12, Hye Ryun Kim13, Sung-Bae Kim14 and Hwan Jung Yun15*
Abstract Background: By investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice. Methods: This is a multi-institutional study enrolled the patients with stage III to IVB LA-HNSCC, except for nasopharyngeal carcinoma, from 2004 to 2015 in thirteen referral hospitals capable of multidisciplinary care. Results: A total of 445 LA-HNSCC patients were analyzed. The median age was 61 years (range, 24–89). The primary tumor location was the oropharynx in 191 (43%), oral cavity in 106 (24%), hypopharynx in 64 (14%), larynx in 57 (13%) and other sites in 27 (6%). The most common stage was T2 in 172 (39%), and N2 in 245 (55%). Based on treatment intents, 229 (52%) of the patients received definitive concurrent chemoradiotherapy (CCRT) and 187 (42%) underwent surgery. Approximately 158 (36%) of the study population received induction chemotherapy (IC). Taken together, 385 (87%) of the patients underwent combined therapeutic modalities. The regimen for definitive CCRT was weekly cisplatin in 58%, 3-weekly cisplatin in 28% and cetuximab in 3%. The preferred regimen for IC was docetaxel with cisplatin in 49%, and docetaxel, cisplatin plus fluorouracil in 27%. With a median follow-up of 39 months, one-year and two-year survival rates were 89 and 80%, respectively. Overall survival was not significantly different between CCRT and surgery group (p = 0.620). Conclusions: In patients with LA-HNSCC, the majority of patients received combined therapeutic modalities. Definitive CCRT, IC then definitive CCRT, and surgery followed by adjuvant CCRT or radiotherapy are the preferred multidisciplinary strategies in real-world practice. Keywords: Locally advanced head and neck cancer, Squamous cell carcinoma, Multidisciplinary treatment, Strategy
* Correspondence: [email protected]; [email protected] † Yun-Gyoo Lee and Eun Joo Kang contributed equally to this work. 3 Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea 15 Department of Internal Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Republic of Korea Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ori
Data Loading...
