Treatments Administered to the First 9152 Reported Cases of COVID-19: A Systematic Review
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REVIEW
Treatments Administered to the First 9152 Reported Cases of COVID-19: A Systematic Review David C. Fajgenbaum
. Johnson S. Khor . Alexander Gorzewski .
Mark-Avery Tamakloe . Victoria Powers . Joseph J. Kakkis . Mileva Repasky . Anne Taylor . Alexander Beschloss . Laura Hernandez-Miyares . Beatrice Go . Vivek Nimgaonkar . Madison S. McCarthy . Casey J. Kim . Ruth-Anne Langan Pai . Sarah Frankl . Philip Angelides . Joanna Jiang . Rozena Rasheed . Erin Napier . Duncan Mackay . Sheila K. Pierson Received: April 24, 2020 Ó The Author(s) 2020
ABSTRACT The emergence of SARS-CoV-2/2019 novel coronavirus (COVID-19) has created a global panDavid C. Fajgenbaum and Johnson S. Khor contributed equally to this study.
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12287996. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40121020-00303-8) contains supplementary material, which is available to authorized users. D. C. Fajgenbaum (&) J. S. Khor A. Gorzewski M.-A. Tamakloe V. Powers R.-A. L. Pai R. Rasheed S. K. Pierson Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA e-mail: [email protected] A. Beschloss L. Hernandez-Miyares B. Go V. Nimgaonkar C. J. Kim S. Frankl P. Angelides J. Jiang Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA J. J. Kakkis University of Pennsylvania, Philadelphia, PA, USA M. S. McCarthy Brown University, Providence, RI, USA
demic with no approved treatments or vaccines. Many treatments have already been administered to COVID-19 patients but have not been systematically evaluated. We performed a systematic literature review to identify all treatments reported to be administered to COVID-19 patients and to assess time to clinically meaningful response for treatments with sufficient data. We searched PubMed, BioRxiv, MedRxiv, and ChinaXiv for articles reporting treatments for COVID-19 patients published between 1 December 2019 and 27 March 2020. Data were analyzed descriptively. Of the 2706 articles identified, 155 studies met the inclusion criteria, comprising 9152 patients. The cohort was 45.4% female and 98.3% hospitalized, M. Repasky Castleman Disease Collaborative Network, Philadelphia, PA, USA A. Taylor The Ohio State University College of Medicine, Columbus, OH, USA E. Napier John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA D. Mackay Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Infect Dis Ther
and mean (SD) age was 44.4 years (SD 21.0). The most frequently administered drug classes were antivirals, antibiotics, and corticosteroids, and of the 115 reported drugs, the most frequently administered was combination lopinavir/ritonavir, which was associated with a time to clinically meaningful response (complete symptom resolution or hosp
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