Tuberculosis Host-Pathogen Interactions
Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-th
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Tuberculosis Host-Pathogen Interactions
Jeffrey D. Cirillo • Ying Kong Editors
Tuberculosis Host-Pathogen Interactions
Editors Jeffrey D. Cirillo Department of Microbial Pathogenesis and Immunology Texas A&M University College of Medicine Bryan, TX, USA
Ying Kong The University of Tennessee Health Science Center Memphis, TN, USA
ISBN 978-3-030-25380-6 ISBN 978-3-030-25381-3 (eBook) https://doi.org/10.1007/978-3-030-25381-3 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Tuberculosis was one of the earliest organisms associated with disease in humans, along with leprosy or Hansen’s disease, and anthrax. Koch demonstrated that a specific disease, tuberculosis, could be caused by Mycobacterium tuberculosis using guinea pigs in the 1880s. The resulting host-bacteria system was used to develop Koch’s postulates, one of the foundations of infectious diseases research, illustrating the importance of understanding both sides of the disease process for infections, the host and pathogen. Prior to the late 1980s, the study of the pathogen that causes tuberculosis was very limited due to the inability to genetically manipulate the organism, but a little over 100 years after Koch’s discovery, molecular genetics became possible in M. tuberculosis, opening a vast array of new studies on these bacteria along with endless possibilities to create novel interventions. Many of the chapters in this book come out of having new abilities to manipulate tuberculosis host-pathogen interactions beyond those previously possible. Our aim is to present some of these more recent findings and novel technologies that have come out
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