Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many
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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer, G.Z. Feuerstein, Z. Zukowska (Editors), 2005 Complement and Kidney Disease, P. F. Zipfel (Editor), 2005 Chemokine Biology: Basic Research and Clinical Application, Volume I: Immunobiology of Chemokines, K. Neote, L. G. Letts, B. Moser (Editors), 2005 Chemokine Biology: Basic Research and Clinical Application, Volume II: Pathophysiology of Chemokines, K. Neote, L. G. Letts, B. Moser (Editors), 2005 The Hereditary Basis of Rheumatic Diseases, R. Holmdahl (Editor), 2005 (Already published titles see last page.)
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Annika B. Malmberg Keith R. Bley Editors
Birkhäuser Verlag Basel · Boston · Berlin
Editors Annika B. Malmberg Elan Pharmaceuticals 800 Gateway Boulevard South San Francisco, CA 94080 USA
Keith R. Bley NeurogesX, Inc. 981F Industrial Road San Carlos, CA 94070 USA
Library of Congress Cataloging-in-Publication Data Turning up the heat on pain : TRPV1 receptors in pain and inflammation / Annika B. Malmberg, Keith R. Bley, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN-13: 978-3-7643-7080-0 (alk. paper) ISBN-10: 3-7643-7080-7 (alk. paper) 1. Nociceptors. 2. Pain. 3. Inflammation. 4. Inflammation--Mediators. I. Malmberg, Annika B., 1966– II. Bley, Keith R. III. PIR (Series) QP451.4.T87 2005 612.8’8--dc22 2005048122
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN-10: 3-7643-7080-7 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7080-0 Birkhäuser Verlag, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2005 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, S
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