Twelve-year incidence of retinal vein occlusion and its trend in Korea
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RETINAL DISORDERS
Twelve-year incidence of retinal vein occlusion and its trend in Korea Jun Young Park 1
&
Sang Jun Park 1
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Seong Jun Byun 1 & Se Joon Woo 1
&
Kyu Hyung Park 1
Received: 16 March 2020 / Revised: 16 June 2020 / Accepted: 17 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To estimate the 12-year incidence and trends of clinically diagnosed retinal vein occlusion (RVO) in Korea. Methods This is a nationwide population-based retrospective study using the Korean national health claims database from 2002 to 2015. The study consisted of the entire Korean population based on the 2015 Census of Population. We identified patients with incident RVO in 2004–2015. We estimated the crude incidence rates and age- and sex-standardized incidence rates in each 12year study period. To determine the trend, we also performed joinpoint regression analyses. Results We identified 240,495 incident RVO cases. The average incidence rate was 48.09 (95% confidence interval [CI], 47.92– 48.27). Women showed a 1.24 times higher incidence rate (53.18 [95% CI, 52.92–53.44]) compared with men (42.78 [95% CI, 42.55–43.02]), while, among patients aged less than 50 years and those aged 80 years or over, men showed higher incidence rates than did women. The highest incidence of 193.56 (95% CI, 191.06–196.06) was observed in the age group of 75 to 79 years. The joinpoint analysis showed an increasing trend of RVO incidence among patients at the age of 70 years and older (annual percentage change, 2.1; 95% CI, 0.2–4.0; p < 0.01). Conclusion RVO is a disease of the elderly that peaks in the late 70s and occurs more in women than in men. In Korea, RVO incidence increased from 2004 to 2015 among the population aged 70 years or older, while among those aged less than 70 years, no trend was observed in RVO incidence rates. Keywords Incidence rate . Epidemiology . Retinal vein occlusion . Trend
Introduction Retinal vein occlusion (RVO), including central RVO (CRVO) and branched RVO (BRVO), is the second most common cause of retinal vascular disease after diabetic retinopathy [1]. When the retinal vein is compressed by the nearby retinal artery, RVO can occur, eventually leading to blood flow turbulence, thrombus formation, and retinal ischemia. In spite of the fact that the previous epidemiologic works have widely reported the prevalence, risk factors, and clinical Jun Young Park and Sang Jun Park contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00417-020-04811-8) contains supplementary material, which is available to authorized users. * Kyu Hyung Park [email protected] 1
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, South Korea
course of RVO, there have been a few investigations with respect to the nationwide incidence of RVO. Among these studies, several large notable cohort studi
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