Type and timing of systemic therapy use predict overall survival for patients with brain metastases treated with radiati
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CLINICAL STUDY
Type and timing of systemic therapy use predict overall survival for patients with brain metastases treated with radiation therapy Kevin Yijun Fan1 · Nafisha Lalani1,2 · Nathalie LeVasseur1,2 · Andra Krauze1,2 · Fred Hsu1,2 · Lovedeep Gondara2 · Kaylie Willemsma2 · Alan McVey Nichol1,2 Received: 14 September 2020 / Accepted: 28 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction This study aimed to investigate whether systemic therapy (ST) use surrounding radiation therapy (RT) predicts overall survival (OS) after RT for patients with brain metastases (BMs). Methods Provincial RT and pharmacy databases were used to review all adult patients in British Columbia, Canada, who received a first course of RT for BMs between 2012 and 2016 (n = 3095). Multivariate analysis on a randomly selected subset was used to develop an OS nomogram. Results In comparison to the 2096 non-recipients of ST after RT, the median OS of the 999 recipients of ST after RT was 5.0 (95% Confidence interval (CI) 4.1–6.0) months longer (p
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