Understanding Evidence-Based Rheumatology A Guide to Interpreting Cr

It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatol

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Understanding EvidenceBased Rheumatology

A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics

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Understanding Evidence-Based Rheumatology

Hasan Yazici • Yusuf Yazici • Emmanuel Lesaffre Editors

Understanding EvidenceBased Rheumatology A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics

Editors Hasan Yazici, MD Istanbul University Beyazit, Istanbul Turkey

Yusuf Yazici, MD New York University School of Medicine NYU Hospital for Joint Diseases New York, NY, USA

Emmanuel Lesaffre, PhD Department of Biostatistics, Erasmus MC Rotterdam, The Netherlands L-Biostat, KU Leuven, Leuven, Belgium

ISBN 978-3-319-08373-5 ISBN 978-3-319-08374-2 (eBook) DOI 10.1007/978-3-319-08374-2 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014948050 © Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

What Should the Reader Expect from This Book? The background for this book is a series of almost-parallel conferences on clinical research methodology organized by the senior and junior Yazici, in either Bodrum or Istanbul by the senior and in New York by Yusuf Yazici. However, it was Emmanuel Lesaffre, our third coeditor and several times a spea