Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort
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ORIGINAL CONTRIBUTION
Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort Lucie Lécuyer1 · Céline Dalle2 · Pierre Micheau2 · Mélanie Pétéra3 · Delphine Centeno3 · Bernard Lyan3 · Marie Lagree4 · Pilar Galan1 · Serge Hercberg1,5 · Adrien Rossary6 · Aicha Demidem6 · Marie‑Paule Vasson6,7 · Valentin Partula1 · Mélanie Deschasaux1 · Bernard Srour1 · Paule Latino‑Martel1 · Nathalie Druesne‑Pecollo1 · Emmanuelle Kesse‑Guyot1 · Stéphanie Durand3 · Estelle Pujos‑Guillot3 · Claudine Manach2 · Mathilde Touvier1 Received: 19 July 2019 / Accepted: 3 January 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures reflecting overall diet in women from the French general population. Methods This cross-sectional study included 160 women in the SU.VI.MAX cohort with detailed dietary data (≥ 10 24-h dietary records) selected according to their level of adherence to the French dietary recommendations, represented by the validated score mPNNS-GS; 80 women from the 10th decile of the score were matched with 80 women from the 1st decile. Plasma metabolomic profiles were acquired using untargeted UPLC-QToF mass spectrometry analysis. The associations between metabolomic profiles and the mPNNG-GS, its components and Principal Component Analyses-derived dietary patterns were investigated using multivariable conditional logistic regression models and partial correlations. Results Adherence to the dietary recommendations was positively associated with 3-indolepropionic acid and pipecolic acid (also positively associated with fruit and vegetable intake and a healthy diet)—2 metabolites linked to microbiota and inversely associated with lysophosphatidylcholine (LysoPC(17:1)), acylcarnitine C9:1 (also inversely associated with a healthy diet), acylcarnitine C11:1 and 2-deoxy-D-glucose. Increased plasma levels of piperine and Dihydro4mercapto-3(2H) furanone were observed in women who consumed a Western diet and a healthy diet, respectively. Ethyl-β-D-glucopyranoside was positively associated with alcohol intake. Plasma levels of LysoPC(17:1), cholic acid, phenylalanine-phenylalanine and phenylalanine and carnitine C9:1 decreased with the consumption of vegetable added fat, sweetened food, milk and dairy products and fruit and vegetable intakes, respectively. Conclusion This study highlighted several metabolites from both host and microbial metabolism reflecting the long-term impact of the overall diet. Trial registration SU.VI.MAX, clinicaltrials.gov NCT00272428. Registered 3 January 2006, https://clinicaltrials.gov/show/ NCT00272428 Keywords Metabolomics · Overall diet · Dietary patterns · Mass spectrometry · 24-h dietary records Lucie Lécuyer and C
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