UV Laser Induced Amino Group Substitution on Pet Ligament to Promote Inhibition of Collagen
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UV LASER INDUCED AMINO GROUP SUBSTITUTION ON PET LIGAMENT TO PROMOTE INHIBITION OF COLLAGEN H.Omuro, K.Hamada*, T.Nakajima*, E.Sinpuku*, M.Nakagawa*, H.Fukuda* and M.Murahara Department of Electrical Engineering, Tokai University Department of Orthopedic Surgery, Tokai University* 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan ABSTRACT An amino functional group was substituted on a PET film surface for the purpose of making the implantation of collagen readily. The PET has been widely used for medical materials such as an artificial ligament because of its strength and antibacterial action. However, when transplanted in human bodies, its compatibility is not good enough to adapt to the collagen which grows from living body tissues. To avoid this reaction medicine has been used clinically which makes the PET fiber into a mesh state and after the transplantation into a human body, makes the tissue intrude in the PET fiber. However, this method has not shown satisfactory enough results to promote rehabilitation. If the living body compatibility of materials is improved the initial adapting power with the tissue can be enhanced. Then we substituted NH2, which has a high affinity for collagen, on the PET surface by ArF laser. PET is highly hydrophobic and does not dissolve well in aqueous solutions. To avoid this reaction we make a thin ammonium fluoride solution layer on the PET surface with capillary phenomenon. Then an ArF laser beam was irradiated vertically onto the sample. The result of this treatment shows that an untreated sample having the contact angle of 80° with water and the bonding strength of only 1.0 kg/cm2 with collagen was improved to have the contact angle of 22° and the bonding strength to be 12 kg/cm2. When the treated sample had been implanted into the subcutaneous tissue of a rabbit’s regiones dorsales, existence of leukocyte colonies that are indicators of human histocompatibility was confirmed on the hydrophilic parts of the sample. INTRODUCTION The number of patients with damaged ligament is increasing along with the aging society, the speeding up of traffic and the popularization of sports. To cure the damaged ligament, it is general to implant the patient’s own iliotibial band and patellar ligament or another person’s ligament that has been kept frozen. Although the implant tissue is necrosed, it is regenerated; however, it is weak in strength [1]. An artificial ligament has been developed for the purpose of resolving this problem since 1975. H.R.Collins presented an artificial ligament which was twisted from Teflon. However, it becomes loose and wears out from friction with bone because the artificial ligament is harder than the anterior cruciate ligament although it has a sufficient tensile strength [2]. And, Kennedy’s LAD (ligament augmentation device) reinforces an implantation patellar ligament and others, but it is not a perfect solution for ligament recovery because the implantation ligament recovery requires load [3]. Leeds University and Keio University have developed an artific
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