Vaccine Analysis: Strategies, Principles, and Control
This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities.Topics covered inc
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cine Analysis: Strategies, Principles, and Control
Vaccine Analysis: Strategies, Principles, and Control
Brian K. Nunnally Vincent E. Turula Robert D. Sitrin •
Editors
Vaccine Analysis: Strategies, Principles, and Control
123
Editors Brian K. Nunnally Apex, NC USA
Robert D. Sitrin Sitrin Solutions, LLC Lafayette Hill, PA USA
Vincent E. Turula Pfizer BioTherapeutics Pharmaceutical Sciences Pearl River, NY USA
ISBN 978-3-662-45023-9 DOI 10.1007/978-3-662-45024-6
ISBN 978-3-662-45024-6
(eBook)
Library of Congress Control Number: 2014956187 Springer Heidelberg New York Dordrecht London © Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Berlin Heidelberg is part of Springer Science+Business Media (www.springer.com)
Foreword
Infections and their associated diseases are arguably the most significant environmental factors impacting individual health, as well as the overall health and wellbeing of populations. The successful development and implementation of interventions to prevent and treat infections over the past two centuries have had a profound positive effect on human and animal health. Among these interventions, the use of vaccines in healthy people for prevention of infection has proven to be one of the most effective, from both public health and economic perspectives. Vaccination has resulted in the eradication of smallpox and, in many parts of the world, substantial control of deadly diseases such as measles, polio, pneumococcal pneumonia, tetanus, diphtheria, rotaviral diarrhea, and hepatitis B. There are numerous other infectious diseases to add to this list, but the control and elimination of these alone have yielded substantial improvements in the quality and quantity of life. Given this, understanding the technical challenges in vaccine development, manufacture, and supply is critical to assure the continuous availability of existing vaccines and to facilitate the intr
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