Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthriti
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ORIGINAL PAPER
Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients Chiaki Narisawa 1 & Kenneth Sutherland 2 & Yutong Lu 3 & Akira Furusaki 4 & Akira Sagawa 4 & Tamotsu Kamishima 3 Received: 24 March 2020 / Revised: 8 August 2020 / Accepted: 14 September 2020 # Society for Imaging Informatics in Medicine 2020
Abstract In rheumatoid arthritis (RA), the radiographic progression of joint space narrowing (JSN) is evaluated using visual assessments. However, those methods are complicated and time-consuming. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. The purpose of this study was to establish the validity of the software that automatically evaluates the temporal change of JSN. This study consisted of 39 patients with RA. All patients were treated with tocilizumab and underwent hand radiography (left and right hand separately) at 0, 6, and 12 months. The JSN was evaluated using mTSS (modified Total Sharp Score) by one musculoskeletal radiologist as well as our automatic system. Software measurement showed that JSDI between 0 and 12 months was significantly higher than that between 0 and 6 months (p < 0.01). While, there was no significant difference in mTSS between 0, 6, and 12 months. The group with higher disease activity at 0 months had significantly higher JSDI between 0 and 6 months than that with lower disease activity (p = 0.02). The automatic software can evaluate JSN progression of RA patients in the finger joint on X-ray. Keywords Rheumatoid arthritis . Radiography . Joint space narrowing . Computer-based analysis
Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction
resulting in severe disability [1, 2]. As current treatment of RA, the main management aim is to reduce the impact of the disease on patients’ lives by improving quality of life and reducing disability [3]. It is widely acknowledged that
Chiaki Narisawa and Kenneth Sutherland contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10278-020-00390-6) contains supplementary material, which is available to authorized users. * Tamotsu Kamishima [email protected] Chiaki Narisawa [email protected]
1
Department of Health Sciences, School of Medicine, Hokkaido University, North-12 West-5, Kita-ku, Sapporo 060-0812, Japan
2
Global Station for Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, North-15 West-7, Kita-ku, Sapporo 060-8638, Japan
3
Faculty of Health Sciences, Hokkaido University, North-12 West-5, Kita-ku, Sapporo 060-0812, Japan
4
Sagawa Akira Rheumatology Clinic, North-1 West-7, Chuo-ku, Sapporo 060-0001, Japan
Kenneth Sutherland [email protected] Yutong Lu luyutong19
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