Do MRI features at baseline predict radiographic joint space narrowing in the medial compartment of the osteoarthritic k
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SCIENTIFIC ARTICLE
Do MRI features at baseline predict radiographic joint space narrowing in the medial compartment of the osteoarthritic knee 2 years later? Ruby Madan-Sharma & Margreet Kloppenburg & Peter R. Kornaat & Stella A. Botha-Scheepers & Marie-Pierre Hellio Le Graverand & Johannes L. Bloem & Iain Watt
Received: 14 August 2007 / Revised: 4 January 2008 / Accepted: 7 April 2008 / Published online: 20 June 2008 # The Author(s) 2008
Abstract Purpose The purpose of the study was to relate magnetic resonance imaging (MRI) features at baseline with radiographically determined joint space narrowing (JSN) in the medial compartment of the knee after 2 years in a group of patients with symptomatic osteoarthritis at multiple joint sites. Materials and methods MRI of the knee and standardized radiographs were obtained at baseline and after 2 years in 186 patients (81% female; aged 43–76 years; mean 60 years). MRI was analyzed for bone marrow lesions, cysts, osteophytes, hyaline cartilage defects, joint effusion, and meniscal pathology in the medial compartment. Radiographs were scored semiquantitatively for JSN in the medial tibiofemoral joint using the Osteoarthritis Research Society International (OARSI) atlas. Radiological progression was defined as ≥1 grade increase. Associations between baseline magnetic resonance (MR) parameters and subsequent radiographic JSN changes were assessed Grant supporter: Pfizer Groton, Groton, CT, USA Pfizer Inc., Groton, CT, USA provided financial support for this work. However, the authors are not employees of Pfizer Inc., retaining full control of inclusion of all data and information that might present a conflict of interest. R. Madan-Sharma (*) : P. R. Kornaat : J. L. Bloem : I. Watt Department of Radiology, Leiden University Medical Center, C3-S, P.O. Box 9600, 2300 RC Leiden, Netherlands e-mail: [email protected] M. Kloppenburg : S. A. Botha-Scheepers Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands M.-P. H. Le Graverand Pfizer Groton, Groton, CT, USA
using logistic regression. Relative risk (RR) was then calculated. Results Radiographic progression of JSN was observed in 17 (9.1%) of 186 patients. Eleven patients had a Kellgren and Lawrence (KL) score of ≥2. A significant association was observed between all patients and meniscal tears (RR 3.57; confidence interval (CI) 1.08–10.0) and meniscal subluxation (RR 2.73; CI 1.20–5.41), between KL
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