Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review
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Rheumatology International https://doi.org/10.1007/s00296-020-04687-1
INTERNATIONAL
SYSTEMATIC REVIEW
Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review Karishma Shah1 · Xiaotian Yang1,2 · Jennifer C. E. Lane1 · Gary S. Collins3,4 · Nigel K. Arden5 · Dominic Furniss1,4 · Stephanie R. Filbay5,6 Received: 17 July 2020 / Accepted: 13 August 2020 © The Author(s) 2020
Abstract Progressive hand interphalangeal joint (IPJ) osteoarthritis is associated with pain, reduced function and impaired quality of life. However, the evidence surrounding risk factors for IPJ osteoarthritis progression is unclear. Identifying risk factors for IPJ osteoarthritis progression may inform preventative strategies and early interventions to improve long-term outcomes for individuals at risk of IPJ osteoarthritis progression. The objectives of the study were to describe methods used to measure the progression of IPJ osteoarthritis and identify risk factors for IPJ osteoarthritis progression. MEDLINE, EMBASE, Scopus, and The Cochrane Library were searched from inception to 19th February 2020 (PROSPERO CRD42019121034). Eligible studies assessed potential risk factor/s associated with IPJ osteoarthritis progression. Risk of bias was assessed using a modified QUIPS Tool, and a best evidence synthesis was performed. Of eight eligible studies, all measured osteoarthritis progression radiographically, and none considered symptoms. Eighteen potential risk factors were assessed. Diabetes (adjusted mean difference between 2.06 and 7.78), and larger finger epiphyseal index in males (regression coefficient β = 0.202) and females (β = 0.325) were identified as risk factors (limited evidence). Older age in men and women showed mixed results; 13 variables were not risk factors (all limited evidence). Patients with diabetes and larger finger epiphyseal index might be at higher risk of radiographic IPJ osteoarthritis progression, though evidence is limited and studies are biased. Studies assessing symptomatic IPJ osteoarthritis progression are lacking. Keywords Hand interphalangeal joint · Osteoarthritis · Risk factors · Disease progression
Introduction Osteoarthritis is one of the leading causes of worldwide disability [1], and, in the USA alone, carries a cost of $10 billion just from economic loss [2]. Hand osteoarthritis is one of the most common types of radiographic osteoarthritis [1]. Hand osteoarthritis also presents in a younger population Conference abstract presentations Some data from this manuscript has been published as a conference abstract: Shah K et al (2020) A systematic review of risk factors and diagnostic methods for hand interphalangeal joint osteoarthritis progression. Osteoarthr Cartil 28(S86–S527): S426. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00296-020-04687-1) contains supplementary material, which is available to authorized users. * Karishma Shah [email protected] Extended author information av
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