Validation of the shortened modified look locker inversion recovery (Sh-MOLLI) sequence for cardiac gated T1 mapping
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Validation of the shortened modified look locker inversion recovery (Sh-MOLLI) sequence for cardiac gated T1 mapping Stefan K Piechnik*, Vanessa M Ferreira, E Dall'Armellina, Stefan Neubauer and Matthew D Robson Address: University of Oxford, Oxford, UK * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O70
doi:10.1186/1532-429X-12-S1-O70
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O70 © 2010 Piechnik et al; licensee BioMed Central Ltd.
Background T1-mapping of the myocardium can potentially detect, quantify and monitor subtle diffuse pathology without the use of contrast agent. One proven method is the MOLLI (Modified Look-Locker Inversion-recovery) technique, offering single-slice T1-mapping based on three sequential inversion-recovery (IR)-prepared experiments in a 17-heartbeat breath-hold. However, long breathholds can limit clinical application in patients. We propose and test a novel variant (Sh-MOLLI) that is approximately two times faster.
Offline post-processing involved manual tracing of endoand epi-cardial contours to calculate T1 statistics in myocardial segments 1 to 16 of the AHA 17-segment model.
Results T1-maps produced by either method did not differ visually. T1-estimates were similar in all but 3 segments (Fig. 1). Across all 160 segments pooled together, Sh-MOLLI T1-estimates were lower by 10.2 ± 24 ms (i.e. -1%, p
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