Rapid cardiac T1 mapping within two heartbeats
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ORAL PRESENTATION
Open Access
Rapid cardiac T1 mapping within two heartbeats Elodie Breton*, Daniel Kim, Sohae Chung, Leon Axel From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction Late gadolinium enhancement (LGE) imaging is an important CMR method than can detect salvageable myocardium after myocardial infarction [1-2]. Recently, T2-weighted-imaging has gained a significant interest to assess myocardial edema [3]. However, clinical interpretation of T 2 -weighted-imaging could be hindered by surface coil effects which yield non-uniform signals. Multi-point T1 mapping approaches, such as Modified Look-Locker inversion recovery (MOLLI) [4], have been proposed to measure myocardial T1, but, as a multiple heartbeat acquisition, it may be sensitive to cardiac motion and arrhythmia. We propose to develop a 2second cardiac T1 mapping pulse sequence for assessment of myocardial edema (pre-contrast) and infarction (post contrast) in patients with acute myocardial infarction. Purpose To develop and validate a cardiac T1-mapping technique. Methods The proposed T1-mapping acquisition consists of 2 TurboFLASH images with centric k-space ordering: proton density-weighted (PDw) image in the first heartbeat and saturation recovery (SR) T1w acquisition in the second heartbeat. A robust non-selective saturation pulse [5] was used to achieve uniform saturation of magnetization. A long delay time=500ms was used to achieve adequate signal-to-noise ratio. The T1w-image was normalized by the PDw image to correct for unknown equilibrium magnetization and receiver coil sensitivity. T1 was calculated algebraically assuming an ideal saturation-recovery equation based on the Bloch equation [6]. Eight healthy volunteers (32±13y.o.) were imaged in a short-axis basal plane at 3T (Tim-Trio, Siemens) at baseline and 10 minutes following 0.05mmol/kg Gd-DTPA injection. All images were acquired in mid-diastole with appropriate NYU Langone Medical Center, New York, NY, USA
trigger delay. Imaging parameters included: FOV=350mm×272mm, matrix=144×112, TE/TR=1.2/ 2.4ms, flip angle=10°, in-plane resolution=2.4mm×2.4mm, GRAPPA ~1.65, temporal resolution=162ms, and receiver bandwidth=990Hz/pix. For validation purposes, myocardial T1 were compared to reference T1 measurements using multi-point SR with TurboFLASH readout (~20s-breath-hold): 1 PDw-image, 12 T1w-images with TD 100to600ms every 100ms, then 800to1800ms every 200ms. A nonlinear LevenbergMarquardt algorithm was used to fit the normalized multi-point SR data. The proposed T1-mapping method was also evaluated in a patient with arrhythmia, before and 20min after administrating 0.15mmol/kg Gd-DTPA.
Results Myocardial T 1 measured using the proposed rapid method were linearly correlated with T 1 measured using the multi-point T 1 method (Fig. 1, slope=0.99,
Figure 1 T1 measured with the T1-mapping method vs. multi-point SR T1 measurements in the LV myocardium.
© 2011 Breton et al; licensee BioMed Central Ltd. This is an open access article distributed und
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