Value of Plasma Methylated SFRP2 in Prognosis of Gastric Cancer
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ORIGINAL ARTICLE
Value of Plasma Methylated SFRP2 in Prognosis of Gastric Cancer Haijiao Yan1 · Wenyu Chen1 · Kele Ge1 · Xizheng Mao1 · Xiaodong Li1 · Wensong Liu2 · Jun Wu1 Received: 27 April 2020 / Accepted: 4 November 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Secreted frizzled-related protein 2 (SFRP2) in circulating tumor DNA (ctDNA) is related to gastric cancer (GC) proliferation. However, whether methylated SFRP2 in ctDNA serves as the biomarker in GC patients remains unknown. Aims To investigate the relationship between methylated SFRP2 and the clinical outcomes of GC patients. Methods One hundred and forty-eight GC patients receiving systemic chemotherapy were collected during 2015–2017. Aberrant SFRP2 methylation was detected before and after chemotherapy by digital PCR-based technologies. Results Baseline SFRP2 methylation positively correlated with lymph node status (P
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