Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggabi
- PDF / 1,870,655 Bytes
- 25 Pages / 595.276 x 790.866 pts Page_size
- 89 Downloads / 156 Views
Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid‑Host Interactome and Their Druggability Ruchika Dadhich1 · Shobhna Kapoor1,2 Received: 24 June 2020 / Accepted: 12 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Lipids form an integral, structural, and functional part of all life forms. They play a significant role in various cellular processes such as membrane fusion, fission, endocytosis, protein trafficking, and protein functions. Interestingly, recent studies have revealed their more impactful and critical involvement in infectious diseases, starting with the manipulation of the host membrane to facilitate pathogenic entry. Thereafter, pathogens recruit specific host lipids for the maintenance of favorable intracellular niche to augment their survival and proliferation. In this review, we showcase the lipid-mediated host pathogen interplay in context of life-threatening viral and bacterial diseases including the recent SARS-CoV-2 infection. We evaluate the emergent lipid-centric approaches adopted by these pathogens, while delineating the alterations in the composition and organization of the cell membrane within the host, as well as the pathogen. Lastly, crucial nexus points in their interaction landscape for therapeutic interventions are identified. Graphic Abstract
Lipids act as critical determinants of bacterial and viral pathogenesis by altering the host cell membrane structure and functions. Keywords Host–pathogen interactions · Virulence-associated lipids · Lipid rafts · Lipid biosynthesis · Membrane organization · Drug development Abbreviations LPS Lipopolysaccharide E. coli Escherichia coli * Ruchika Dadhich [email protected] * Shobhna Kapoor [email protected] 1
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India
Wadhwani Research Centre for Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India
2
STEC Shiga toxin producing Escherichia coli HUS Hemolytic uremic syndrome Mtb Mycobacterium tuberculosis TB Tuberculosis OM Outer membrane IM Inner membrane PE Phosphatidyl ethanolamine PG Phosphatidylglycerol PS Phosphatidylserine Cer Ceramides SM Sphingomyelin
13
Vol.:(0123456789)
CL Cardiolipin TLR Toll-like receptors MD Myeloid differentiation factor GUV Giant unilamellar Vesicles Stx Shiga toxin Gb3 Globotriaosylceramide FRET Fluorescence resonance energy transfer GSL Glycosphingolipids DRM Detergent-resistant membranes MV Microvesicles EHEC Enterohemorrhagic Escherichia coli EPEC Enteropathogenic Escherichia coli UPEC Uropathogenic Escherichia coli PDIM Phthiocerol dimycocerosate TDM Trehalose Dimycolate SL Sulfoglycolipid PIM Phosphatidylinositol mannoside Man-LAM Mannose capped lipoarabinomannan PGL Phenolic glycolipid DAG Diacylglycerol DPPG Dipalmitoyl phosphatidylglycerol DMPG Dimyristoyl phosphatidylglycerol PAL Peptidoglycan associated lipids CLR C-type lectin receptor CR Compliment recept
Data Loading...
